ࡱ> ^`] bjbj 0X  D"$""""""",${'ZJ"J"__"___j"_"__  +߃ި^ "u"0" ,'_' _  J"J"_"' ^:    Population Genetics 70901 Fall 2013 Nothing in biology makes sense except in the light of evolution. T.H. Dobzhansky, 1973 Nothing in evolution makes sense except in the light of population genetics. Michael Lynch, 2007 Nothing in population genetics makes sense except in the light of coalescent theory. Instructor Dr. Mike Hickerson Office: 835 Marshak; City College; Office hours location: CUNY GC location TBA Office Hours: Tuesday 2:00-4:00 pm e-mail: mhickerson@ccny.cuny.edu Course details: Lecture: Tues 9:30am -12:30pm at the CUNY GC; room = TBA Final Exam: TBA Texts: An introduction to Population Genetics by Nielsen and Slatkin, 2013 edition Grading: Homework 160 pts 8 homeworks Discussion 80 pts 8 Discussions Midterm 100 pts Final Exam 110 pts Final Project 50 Total 500 pts Re-grading policy: Requests for re-grades must be made within one week of the assignment being handed back to the student. Only assignments/exams done in pen can be submitted for a regrade. Midterms will only be regarded if it has the potential to affect your final grade. Homework Assignments: An assignment will sometimes be given during a lecture, due one week later in the beginning of lecture. You are free to work in groups, but each individual is responsible for writing up and understanding the material separately. Late penalty will be 20% of the assignments value per week late. Final project will involve either a literature review or setting up/designing and preliminary analysis (real or simulated data). Paper-based discussions: On some of the weeks, we will have a discussion in the 2nd half of the class. In this case, two randomly selected people will lead the discussion on the assigned paper. The actual paper assignment will be given the week before. After you lead two discussions, you are off the hook Project Presentation: Each student will have a choice of either 1.) presenting a literature review of some particular population genetics subject of interest or 2.) conduct and present a new analysis of population genetic data. Both projects are to be modest in scope, but can lead to a downstream publication. Tentative Course Schedule Date: TopicReading Sept 3inChapt 1 1-4 Sept 3Allele and genotype frequenciesChapt 1, 5-11 Sept 3Hardy-Weinberg EquilibriumChapt 1, 12-20 Sept 10( * Genetic drift and mutationChapt 2, 21-31 Sept 17* Coalescent theoryChapt 3, 35-58 Sept 24*(Population SubdivisionChapt 4, 59-76 Oct 1*(Inference of Population History Chapt 5, 154-183 Oct 8(Linkage Disequilibrium and gene mappingChapt 6, 1-7-128 Oct 15 No class (Monday schedule)  Oct 22Midterm Review (details TBA)  Oct 29MIDTERM Nov 5 (SelectionChapt 7, 129-152 Nov 5*(Selection IIChapt 8, 153-178 Nov 12Neutral TheoryChapt 9, 179-194 Nov 19*(Selection III (interactions and conflict)Chapt 10, 195-214 Nov 26(Quantative Genetics and the Price EquationChapt 11, 215-232 Dec 3*Project PresentationsDec 10Project PresentationsDec 17FINAL EXAM * Indicates homework due (assigned Tue before). ( Indicates paper based discussion (assigned Tue before) $&i+ < ? A B L M N R ` b ǿ崩|sg[h5Hhl?CJ\aJh5Hh5HCJ\aJhl?CJ\aJh\D.CJ\aJhiiCJ\aJhmCJ\aJhh|aCJ\aJh CJ\aJh 5CJ\aJhl?5CJ\aJhH8ahl?5 h 5 h 6h h 6hGh hl?6hl?h hi h CJh!hdrCJ!%&i? @ A B M N b C S T gdl?gd  $@&a$gdl?   * + B C N O R S T \ o t ƽxoe_VP hl?CJhYhl?CJ heJCJh hl?5CJhAhl?CJh8`@CJaJhiiCJaJh hl?5CJaJh hl?5\aJhl?5\aJhl?CJaJhH8ahl?CJ\aJhl?CJ\aJh CJ\aJh5Hh>.CJ\aJh5HhdrCJ\aJh5Hhl?CJ\aJh5Hh CJ\aJ     ) . / 0 5 6 N Q ] ^ ` e f w | } > hCJ h&CJh2hl?5CJ h`5CJ hX5CJ h{p5CJhhl?5CJ h{pCJ h`CJ hS CJ hXCJh hl?5CJh hl?CJ hl?CJ heJCJ6T   6 N e f | } ?Atu  gdwA ^`gd{p`gdl?gd8`@@&gdl?>?<stu횐zqk h,_CJhUwhbCJ hM.CJhUwhl?CJ hUwhl?hUwhl?5CJh!hl?5 hh5 hh(5 h\D.h\D.h\D. h\D.5 h5 h&h&hhJXh{ph&h&H*h&h&h&5 h&5 hl?5 hwA5h\Jhl?CJ(]TC $If^gd,_ $IfgdM.kd$$IflF*,"|  t6    44 l` ap$If $Ifgdl?")+/0126789ST[]_`bcdeijlmnoqմ꓍ hUwh?fpwxy &'()/ h9dCJ hV(7CJhUwh`CJ h`CJ hUwh$$IflF*,"|  t6    44 l` ap67?gxlcZQ $Ifgd` $Ifgdl? $IfgdIkd$$IflF*,"|  t6    44 l` apxylcZTcc$If $IfgdI $Ifgdl?kd$$IflF*,"|  t6    44 l` aplcZTK $Ifgdl?$If $Ifgd` $IfgdIkd]$$IflF*,"|  t6    44 l` aplc]T $Ifgdl?$If $IfgdIkd$$IflF*,"|  t6    44 l` aplc]T $Ifgd9d$If $IfgdIkd$$IflF*,"|  t6    44 l` ap 'lcZQ $Ifgd9d $Ifgdb $IfgdIkd|$$IflF*,"|  t6    44 l` ap'(0?Plc]T $Ifgd9d$If $IfgdIkd1 $$IflF*,"|  t6    44 l` ap/0>HOPQRWXYZ[$%/12569:=>@Slnop޽޽޽޽ jh&CJ hCJh'<hl?CJ hl?CJ huCJ hUwhhUwhCJ hyCJ jhCJ jh9CJ hCJ ho~~~uuu  gdl?h^hgdl?wkd^$$Ifl0*|  t6 44 l` apyt ;ph2hl?CJ hn0#CJ hl?5CJh'<h&CJ h:$CJ h~CJ h&CJ.:pl?/ =!"#F$% $$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` p$$If!vh#v#v|#v :V l  t655|5 ` pyt!$$If!vh#v#v|#v :V l  t655|5 ` pyt666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ OJPJQJ_HmH nH sH tH @`@ fNormalCJ_HaJmH sH tH J@BJ 2 Heading 4 @&XDYD5OJQJaJDA D Default Paragraph FontRi@R Table Normal4 l4a (k ( No List 6U`6 !0 Hyperlink >*B*phP@P !Colorful Grid - Accent 1:V0 44j@ j j 6_j 6_j j LB*CJaJph B*ph B*ph5B*\ph5\O !PMedium Grid 31,:V0 44jQ@ jQ jQ j; jQ jQ pCJaJ56B*\]ph56B*\]ph56B*\]ph56B*\]phj#j ! Table Grid7:V0@2@ 2 List Paragraph ^m$DoAD 2Heading 4 Char5OJQJaJP^@RP 20 Normal (Web) XDYDCJOJQJ^JaJFV`aF jJ0FollowedHyperlink >*B*phD@rD 10 Balloon TextCJOJQJaJJoJ 10Balloon Text CharCJOJQJaJB'`B Y Comment ReferenceCJaJ4@4 Y 0 Comment Text:: Y 0Comment Text CharHj@H Y 0Comment Subject5CJ\aJNoN Y 0Comment Subject Char5CJ\aJPK!pO[Content_Types].xmlj0Eжr(΢]yl#!MB;.n̨̽\A1&ҫ QWKvUbOX#&1`RT9<l#$>r `С-;c=1g'}ʅ$I1Ê9cY<;*v7'aE\h>=,*8;*4?±ԉoAߤ>82*<")QHxK |]Zz)ӁMSm@\&>!7;ɱʋ3װ1OC5VD Xa?p S4[NS28;Y[꫙,T1|n;+/ʕj\\,E:! t4.T̡ e1 }; [z^pl@ok0e g@GGHPXNT,مde|*YdT\Y䀰+(T7$ow2缂#G֛ʥ?q NK-/M,WgxFV/FQⷶO&ecx\QLW@H!+{[|{!KAi `cm2iU|Y+ ި [[vxrNE3pmR =Y04,!&0+WC܃@oOS2'Sٮ05$ɤ]pm3Ft GɄ-!y"ӉV . `עv,O.%вKasSƭvMz`3{9+e@eՔLy7W_XtlPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-!pO[Content_Types].xmlPK-!֧6 -_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!!Z!theme/theme/theme1.xmlPK-! ѐ'( theme/theme/_rels/themeManager.xml.relsPK]# X >/p !+T 0c6x'P159<  "#$%&'()*8@0( CBCB B S  ?nu25 $! ::::::p* R^`OJPJQJ^Jo( ^`OJQJo(o p^p`OJQJo( @ ^@ `OJQJo( ^`OJQJo(o ^`OJQJo( ^`OJQJo( ^`OJQJo(o P^P`OJQJo(pư:T        >=&i]kabS ii9 U n0#:$h(M.>..(7|>85],󴥲94{d}d{i݄?u~!ɗhXܭg?@ABCDEFGHJKLMNOPQRSTVWXYZ[\_Root Entry F߃ިaData -1Table5'WordDocument0XSummaryInformation(IDocumentSummaryInformation8UCompObj` F Microsoft Word 97-2004 DocumentNB6WWord.Document.8